| Pair Name | Alpha-Carotene, Paclitaxel | ||
| Phytochemical Name | Alpha-Carotene (PubChem CID: 6419725 ) | ||
| Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
| Structure of Phytochemical |
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2D
MOL
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| Structure of Anticancer Drug |
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| Pair Name | Alpha-Carotene, Paclitaxel | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Inhibition-->Cell metastasis | |||
| Gene Regulation | Down-regulation | Expression | MMP2 | hsa4313 |
| Down-regulation | Expression | MMP9 | hsa4318 | |
| Down-regulation | Phosphorylation | PTK2 | hsa5747 | |
| Up-regulation | Expression | SERPINE1 | hsa5054 | |
| Up-regulation | Expression | TIMP1 | hsa7076 | |
| Up-regulation | Expression | TIMP2 | hsa7077 | |
| In Vitro Model | 3LL | Malignant tumors of the mouse pulmonary system | Mus musculus (Mouse) | CVCL_5653 |
| In Vivo Model | Approximately 2×10⁶ LLC cells (0.1 ml/mouse) were injected (s.c.) into the right flank of mice. | |||
| Result | We demonstrate that AC effectively inhibits LLC metastasis and suppresses lung metastasis in combination with taxol in LLC-bearing mice, suggesting that AC could be used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Alpha-carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice. J Nutr Biochem. 2015 Jun;26(6):607-15. doi: 10.1016/j.jnutbio.2014.12.012. | Click |
